The Bacillus subtilis chromatin-associated protein Hbsu is involved in DNA repair and recombination
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Genetic recombination in Bacillus subtilis 168: effect of DeltahelD on DNA repair and homologous recombination.
The B. subtilis DeltahelD allele rendered cells proficient in transformational recombination and moderately sensitive to methyl methanesulfonate when present in an otherwise Rec(+) strain. The DeltahelD allele was introduced into rec-deficient strains representative of the alpha (recF strain), beta (addA addB), gamma (recH), epsilon (DeltarecU), and zeta (DeltarecS) epistatic groups. The Deltah...
متن کاملGenetic Recombination in Bacillus subtilis 168: Effect of DhelD on DNA Repair and Homologous Recombination
The B. subtilis DhelD allele rendered cells proficient in transformational recombination and moderately sensitive to methyl methanesulfonate when present in an otherwise Rec strain. The DhelD allele was introduced into rec-deficient strains representative of the a (recF strain), b (addA addB), g (recH), « (DrecU), and z (DrecS) epistatic groups. The DhelD mutation increased the sensitivity to D...
متن کاملA novel SMC-like protein, SbcE (YhaN), is involved in DNA double-strand break repair and competence in Bacillus subtilis
Bacillus subtilis and most Gram positive bacteria possess four SMC like proteins: SMC, SbcC, RecN and the product of the yhaN gene, termed SbcE. SbcE is most similar to SbcC but contains a unique central domain. We show that SbcE plays a role during transformation in competent cells and in DNA double-strand break (DSB) repair. The phenotypes were strongly exacerbated by the additional deletion ...
متن کاملRole of LrpC from Bacillus subtilis in DNA transactions during DNA repair and recombination
Bacillus subtilis LrpC is a sequence-independent DNA-binding and DNA-bending protein, which binds both single-stranded (ss) and double-stranded (ds) DNA and facilitates the formation of higher order protein-DNA complexes in vitro. LrpC binds at different sites within the same DNA molecule promoting intramolecular ligation. When bound to separate molecules, it promotes intermolecular ligation, a...
متن کاملBacillus subtilis polynucleotide phosphorylase 3′-to-5′ DNase activity is involved in DNA repair
In the presence of Mn(2+), an activity in a preparation of purified Bacillus subtilis RecN degrades single-stranded (ss) DNA with a 3' --> 5' polarity. This activity is not associated with RecN itself, because RecN purified from cells lacking polynucleotide phosphorylase (PNPase) does not show the exonuclease activity. We show here that, in the presence of Mn(2+) and low-level inorganic phospha...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 1997
ISSN: 0950-382X,1365-2958
DOI: 10.1046/j.1365-2958.1997.3061670.x